HORDB

ID: hor001891
Uniprot ID: P0DJ95
Protein name: PACAP-related peptide
Gene name: Adcyap1
Organism: Heloderma suspectum (Gila monster)
Family: Glucagon family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Heloderma (genus), Helodermatidae (family), Neoanguimorpha, Anguimorpha (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
GO BP: GO:0007165 signal transduction; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0010628 positive regulation of gene expression; GO:0030073 insulin secretion; GO:0060124 positive regulation of growth hormone secretion
GO CC: GO:0005576 extracellular region

Function: Promotes neuron projection development
Mechanism: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cell
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001891_AF2.pdb

hor001891_ESM.pdb

Mass:	312990	Formula:	C126H206N36O30S
Absent amino acids:	CDEPTW	Common amino acids:	L
pI:	11.15	Basic residues:	6
Polar residues:	6	Hydrophobic residues:	9
Hydrophobicity:	-14.35	Boman Index:	-3188
Half-Life:	20 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	106.09
Instability Index:	881.74	Extinction Coefficient cystines:	2980
Absorbance 280nm:	135.45